Catalog / 替莫唑胺

替莫唑胺

Temozolomide

现货杂环-咪唑并四嗪抗肿瘤药 API/活性药物成分

Molecular Structure

CAS Number

85622-93-1

Molecular Formula

C6H6N6O2

Molecular Weight

194.15

Purity

≥98%

InChIKey

BPEGJWRSRHCHSN-UHFFFAOYSA-N

SMILES

CN1C(=O)N2C=NC(=C2N=N1)C(=O)N

Appearance

White to light pink solid

Melting Point

212 °C (decomposition)

Solubility

5.09 g/L in water at 25°C

Storage

Store at 2-8°C, protect from moisture and light

Description

替莫唑胺（Temozolomide, TMZ）是一种口服烷化剂类抗肿瘤药物，用于治疗胶质母细胞瘤和多形性胶质细胞瘤。属于咪唑并四嗪类化合物，在生理pH下自发水解产生活性代谢物MTIC（3-甲基-(三氮烯-1-基)咪唑-4-甲酰胺），通过甲基化DNA鸟嘌呤的O6和N7位点诱导肿瘤细胞凋亡。FDA批准用于新诊断胶质母细胞瘤的联合放疗及复发间变性星形细胞瘤的治疗。

Applications

抗肿瘤药物（脑肿瘤：胶质母细胞瘤、间变性星形细胞瘤）；医药中间体；科研试剂

Safety & Hazards

Classification: Acute Tox. 2; Skin Irrit. 2; Eye Irrit. 2; STOT SE 3; Muta. 1B; Carc. 1B; Repr. 1B; STOT RE 1

H-statements: H300; H302; H315; H319; H335; H340; H350; H360; H372

P-statements: P203; P260; P261; P264; P270; P271; P280; P301+P316; P302+P352; P304+P340; P305+P351+P338; P318; P319; P321; P330; P332+P317; P337+P317; P362+P364; P403+P233; P405; P501

Availability

Status Check Availability

Purity ≥98%

Grade 试剂级

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